Understanding how methodological aspects affect the release of trace metal(loid)s from urban dust in inhalation bioaccessibility tests

The bioaccessibility of metal(loid)s in ambient particulate matter (PM) has been recently used to represent the risk inhalation exposure. Nevertheless, different methodological factors affect values; among these, type and composition surrogate biological fluids liquid solid ratio have revealed be most important. To better understand how these aspects bioaccessibility, a reference material corresponding urban dust (SRM1648a) was contacted with synthetic commonly literature representing that may interact fine (Gamble’s solutions, artificial lysosomal fluid (ALF)) coarse particles (gastric fluid), for (L/S) ratios ranging from 500 20,000. Visual MINTEQ 3.1. enhance discussion on solubility metals leaching solution depends simulated speciation metals. results obtained indicate small change Gamble’s (the presence glycine) increase significantly at L/S 5,000. highest studied 5,000 found ALF fluid. study effect showed increased logarithmically increasing ratio, while it remained practically constant gastric This behavior is explained assuming solubility-controlled, availability-controlled.